Protein Details: Small conductance calcium-activated potassium channel protein 2

Protein ID

ICDB_Pro_0688

Protein Name

Small conductance calcium-activated potassium channel protein 2

Gene Name

Kcnn2

Organism

Rattus norvegicus (Rat)

Length

580 amino acids

AlphaFoldDB

AF-P70604-F1-model_v4.pdb

Function

Forms a voltage-independent potassium channel activated by intracellular calcium . Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization

Sequence

MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS

PDB Structures

1G4Y 1KKD 1QX7 2PNV 3SJQ 4G27 4G28 4J9Y 4J9Z 4QNH 6CZQ

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Brain.

DOI ID

10.1126/science.273.5282.1709; 10.1038/26758; 10.1073/pnas.0600895103; 10.1074/jbc.m110.110072; 10.1038/35074145

RefSeq

NP_062187.1